Inside-Out Signaling
نویسندگان
چکیده
منابع مشابه
Inside Out
I have alwayswanted to be adoctor.Manyaspects ofmedicine enthralled me: research, diagnosis, and the possibility of improving a patient’s quality of life, in particular.Walking the corridors of a hospital felt exhilarating. At 15 I had a volunteer position at the local hospital. Although my assignments were answering phones, directing visitors, and, my favorite, delivering goods topatients, I f...
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Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage as well as mitochondria-dependent generation of reactive oxygen species. DNA damage causes activation of ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related protein, which induce cell cycle checkpoints and also modulate the activation of prosurvival and proapoptotic signalin...
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Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and allergic responses. S1P levels inside cells are tightly regulated by the balance between its synthesis by sphingosine kinases and degradation. S1P is interconvertible with ceramide, which is a critical med...
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Integrins dynamically equilibrate between three conformational states on cell surfaces. A bent conformation has a closed headpiece. Two extended conformations contain either a closed or an open headpiece. Headpiece opening involves hybrid domain swing-out and a 70 Å separation at the integrin knees, which is conveyed by allostery from the hybrid-proximal end of the βI domain to a 3 Å rearrangem...
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peace accords signed between 1988 and 1998, thirty-one failed to last more than three years.1 Contributing to their failure was the behavior of so-called spoilers: those who use violence or other means to undermine negotiations in the expectation that a settlement will threaten their power or interests.2 The stakes for understanding spoiler behavior are high. Where parties kept spoilers at bay,...
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ژورنال
عنوان ژورنال: Circulation
سال: 2015
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.115.016978